:itsme: Potential problems with the use of nitrous oxide (N2O) include which of the following?

(1) Use of 70% N2O during a general anesthetic for which an ETT is used can result in a doubling or tripling of the size of the ETT cuff & subsequent excessive pressure on tracheal mucosa

(2) N2O reduces the cobalt in Vitamin B12, which causes inactivation of thymidine synthetase & the production of mutations in DNA

(3) N2O exposure has been associated with an increased incidence of spontaneous abortions in pregnant women but not with an increased incidence of birth defects

(4) Unless supplemental oxygen is given after discontinuation of 70% N2O, diffusion hypoxia may occur because N2O is 5x as soluble as nitrogen in blood

Any or all of the answers may be correct!