All of the following statements are true about hypoxic pulmonary vasoconstriction (HPV) EXCEPT:

A) HPV is a local response of bronchiolar artery smooth muscle in underventilated areas of the lung
B) HPV is responsible for most lung perfusion redistribution during one-lung ventilation
C) HPV occurs in areas of the lung with low alveolar oxygen pressure
D) HPV allows the lung to maintain optimal ventilation/perfusion matching