Im trying to wrap my head around this (currently in nursing school hope y'all don't mind me asking this question here...). Ok so cholinergics give the same effects as when the PSNS is stimulated so I understand for example the drug bethanechol. Causes increased urination, GI tone, motility blah blah blah. What it throwing me a bit is the direct acting vs indirect acting cholinergics. Why does SUX cause neuromuscular blockage as a direct acting cholinergic but indirect acting cholinergics cause skeletal muscle contractions and are used for myasthenia gravis? Thanks for your help in advance. I hear about SUX all the time on here so I was excited to see it in my book but then I was bummed that the mechanism of action is not explained further.

Andrea