Ok, fair enough. One of the hats we CRNA's wear is "pharmacologic expert". Where has pris "been argued" as 'toxicity'? Can you defend it? in my pharmacology training, "toxicity" has always meant adverse effects secondary to overdose. Also, while you're at it Ether, for our young (and not so young) aspirants, distinguish between "adverse reaction" and "overdose". To wit: What is the difference between an adverse reaction to fentanyl and an overdose of fentanyl?